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Human Cases of Avian Influenza Infections in 2014

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In 2014, 366 human cases of avian influenza infection from four subtypes, A(H7N9), A(H5N1), A(H5N6) and A(H10N8) were reported from 7 countries, China, Egypt, Taiwan, Malaysia, Cambodia, Indonesia, and Vietnam. The case-fatality risk ranged from possibly as low as .22 to as high as .67 among these subtypes in 2014. There is no evidence among any of these subtypes of sustained human-to-human transmission. Influenza viruses that easily circulate among human populations are referred to as seasonal influenza viruses and can cause severe illness in 3 to 5 million individuals annually.[1] Avian influenza Type A viruses that cause infection in birds are referred to as avian influenza viruses. These viruses occur naturally among wild birds worldwide and can infect domestic poultry and other bird and animal species.[2] These avian influenza viruses circulating in bird populations do not usually infect humans. However, sometimes humans can become infected with avian influenza subtypes which hav...

A Comparative Discussion of the Influenza A(H7N9) and Influenza A(H5N1) Outbreaks

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The first human cases of infection from a reassortant avian influenza  A(H7N9) virus were reported from the People’s Republic of China (China) on March 31, 2013.[1] Since then more than 145 confirmed and probable human cases of H7N9 infection have been officially reported. Of the cases reported through December 31, 2013, about 71% are male and 29%, female. Among the reported cases, the ages range from 2 years old to 91 years old. The median age is 60. Besides two imported case in Taiwan, one in April and one in December 2013, all other H7N9 have occurred within the country of China. A recent summary of human H7N9 cases is presented on pages 102 and 103 in Update on the situation of avian influenza A(H7N9) infection by the Hong Kong Centre for Health Protection.[2] Another current summary is available from the European Center for Disease Prevention and Control.[3] The last official World Health Organization (WHO) tabulation of cases was published in October 25, 2013.[4]   ...

A Review of Human Influenza A(H5N1) Cases in 2013

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In 2013, 38 human cases of Influenza A(H5N1)  were reported from around the world. This number represents an 18% increase over the number of reported cases in 2012. Six countries reported cases in 2013, Bangladesh, Cambodia, China, Egypt, Indonesia, and Vietnam. Cambodia reported about 71% (27) of all cases reported in 2013.   In 2013, children younger than 10 years old represent about 63% of all cases. No human clusters were reported in 2013. Relative to other countries, Cambodia experienced the greatest percentage increase in human infections in a short period of time. The continued low frequency of reported infections does not eliminate H5N1 as a pandemic threat.   Influenza A(H5N1), (often referred to “bird flu” or avian influenza or HPAI), is an emerging infectious disease. It was first detected in humans in Hong Kong in 1997. Since 2003, the World Health Organization (WHO) has been monitoring human outbreaks of H5N1. Through December 31, 2013, WHO has offi...